The website http://Themedicalbiochemistrypage.org provides detailed information in regards to biological and chemical functions of the human body including topics such as metabolism, vitamins and minerals. Each of theses categories is followed by subcategories, which includes effects of deficiency and or disease pertaining to a biochemical function or in other cases more detailed references. For example, Amino Acid Metabolism has several subcategories which include an introduction to amino acid metabolism, essential versus non-essential amino acids, and inborn errors in amino acids. By selecting one of these three, will bring you to a list and of various amino acids. Each amino acid listed includes its structure and detailed function. Other main biochemistry categories include protein synthesis, enzyme kinetic, hemoglobin, myoglobin, etc. This website has proved to be extremely informative, as a dictionary or encyclopedia for biochemistry terms, functions and reactions. It is extremely organized, allowing for a quick and efficient search.
http://themedicalbiochemistrypage.org/
Tuesday, March 9, 2010
What Knowledge have you connected with past knowledge?
The past knowledge I have obtained from general chemistry, biology and nutrition have all provided a connection to biochemistry. Chemistry is the science of matter which deals with the composition of substances. Chemistry looks at individual elements and molecular reactions in respect to their properties. Biochemistry looks at the bigger picture, in relation to the molecular reactions occurring, or the chemistry, and its effects on the biological make up of organisms.
Biology is the study of living organisms, along with their structure, function, origin and evolution. Organisms are broken up into different domains. The main focuses of biochemistry revolves around such living organisms, prokaryote's and eukaryote's. These two domains differ in comparison of organelles, which provide certain function to the cell. All cells contain DNA. The DNA that makes up a cell is referred to as the genome composed of genes.
Nutrition is the process by which an organism assimilates food and uses it for growth. In nutrition it was learned that the body needs an approximate amount of various nutrients to function properly. Vitamins are the key to regulation in a living organism. A lack of, can result in metabolic dysfunction and off set equilibrium. Biochemistry has connected the nutritional education of dietary need, which was learned in nutrition, and the chemical function they play within the body's cells. For example, the calcium potassium pump in relation to muscle contraction and relaxation. All in all, my past knowledge in many different areas of science correlate and connect with my new and present knowledge in biochemistry.
Find a protein using PDB explorer-describe your protien, including what disease state or other real-world application it has.
Calsequestrin, locus 1SJI, is a calcium storage protein for both cardiac and skeletal muscle tissue. It is responsible for binding and releasing calcium (2+) ions. These ions make it possible for the contraction and relaxation cycle to process effectively. This protein undergoes coupled calcium binding and protein polymerization. It is related to the taxonomy, Canis Lupus Familiaris or dogs.
It is shown that two structures of skeletal and cardiac Calsequestrin are superimposable due to their subunits and front to front dimers. In other words they are overlapping one another. Thus, in comparing cardiac and skeletal muscle absorbtion shows, 80 Ca(2+) per skeletal Calsequestrin and 60 (2+) per cardiac Calsequestrin. This proposes a negative 80 and 69 net charge resulting in the C-27 terminal of the amino acid within cardiac muscle Calsequestrin to become deleted. This results in a 50% Ca (2+) binding reduction and a loss of a Ca(2+) tetramer formation. The tetramer formation is essential for biological activity and function. The Loss of tetramer formation can be linked to the loss of inefectivity of the protien and lack of phage inactivity.
http://www.ncbi.nlm.nih.gov/Structure/mmdb/mmdbsrv.cgi?uid=1SJI
www.springerlink.com/index/T73Q0X5V85HJ820Q.pdf
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